Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics – quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few examples of Cisterna’s powerful technologies being used to achieve our goal of 10x higher quality mRNA for therapeutic application.
Cisterna Biologics is at the forefront of mRNA-based therapeutics, dedicated to providing exceptionally high-quality mRNA. Our mission is to address the multifaceted challenges in mRNA production for research and development, including quality, quantity, cost, and delivery lead time. As mRNA technology evolves, we are committed to delivering rapid, innovative, and effective solutions to unlock its boundless potential as a therapeutic modality.
Cisterna Biologics offers SPECC-purified mRNA to qualified customers on a research use only (RUO) basis. For detailed pricing information, please reach out to our team.
Cisterna Biologics is powered by a team of experts dedicated to advancing mRNA technology. Our team is committed to providing reliable and innovative solutions to meet the demanding needs of mRNA-based therapeutic applications.
Engineering cells to unlock the next generation of mRNA medicines
Next-generation mRNA medicines
Kernal is creating mRNA 2.0 therapies that work in specific cells
Delivering RNA therapies.
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